Distribution of 5-HT3, 5-HT4, and 5-HT7Receptors Along the Human Colon

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Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon

BACKGROUND/AIMS Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-as...

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Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in mammals, including humans. This raises the question of how these antagonists inhibit GI-motility and transit, if depletion of endogenous 5-HT does no...

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comparison of 5-ht3 or 5-ht4 agents function into the prelimbic area on passive avoidance memory consolidation

growing evidence suggests that serotonin plays an important role in learning and memory and all its receptors might be implicated in this process. the present study aimed at investigating and comparing the possible involvement of 5-ht 3 and 5-ht 4 receptor (r) agonists/antagonists upon consolidation of inhibitory avoidance memory in the pre-limbic (pl) area. bilateral intra-pl microinjections o...

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We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to modify 5-HT-accelerated colonic transit in conscious rats, but the 5-HT3 and 5-HT4 receptor dual antagonist FK1052 prevented the enhancement. In this study, the inhibitory effect on the stimulated colonic transit was not also observed with 5-HT4 receptor antagonists (SDZ205-557 and SB204070) in freely movi...

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ژورنال

عنوان ژورنال: Journal of Neurogastroenterology and Motility

سال: 2015

ISSN: 2093-0879,2093-0887

DOI: 10.5056/jnm14157